Programmatic Theme: Translational Bioinformatics

Abstract: Alzheimer’s Disease (AD) progression is complex and multifactorial. Identifying genetic markers associated with neurodegenerative progression is essential for preventative measures and early treatment. Here, we associated single-nucleotide polymorphisms with a progression-based imaging phenotype in a cohort of subjects at a high risk of developing AD. Mapping significantly associated SNPs to adjacent genes, we identified enriched pathways with reported associations to AD. This methodology can be extended to be used as a clinical risk estimation tool for AD progression.

Learning Objective: To associate single-nucleotide polymorphisms with a progression-based imaging phenotype in a cohort of subjects at high risk of developing AD.

Authors:

Danilo Pena (Presenter)
University of Texas Health Science Center at Houston

Assaf Gottlieb, University of Texas Health Science Center at Houston
Luca Giancardo, University of Texas Health Science Center at Houston